FoxM1 promotes glioma cells progression by up-regulating Anxa1 expression.
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ABSTRACT:
SUBMITTER: Cheng SX
PROVIDER: S-EPMC3753245 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
FoxM1 promotes glioma cells progression by up-regulating Anxa1 expression.
Cheng Shi-Xiang SX Tu Yue Y Zhang Sai S
PloS one 20130826 8
Forkhead box M1 (FoxM1) is a member of the forkhead transcription factor family and is overexpression in malignant gliomas. However, the molecular mechanisms by which FoxM1lead to glioma carcinogenesis and progression are still not well known. In the present study, we show that Anxa1 was overexpression in gliomas and predicted the poor outcome. Furthermore, Anxa1 closely related to the FoxM1 expression and was a direct transcriptional target of FoxM1. Overexpression of FoxM1 up-regulated Anxa1 e ...[more]
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