Ontology highlight
ABSTRACT:
SUBMITTER: Poutahidis T
PROVIDER: S-EPMC3753256 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Poutahidis Theofilos T Cappelle Kelsey K Levkovich Tatiana T Lee Chung-Wei CW Doulberis Michael M Ge Zhongming Z Fox James G JG Horwitz Bruce H BH Erdman Susan E SE
PloS one 20130826 8
A role for microbes has been suspected in prostate cancer but difficult to confirm in human patients. We show here that a gastrointestinal (GI) tract bacterial infection is sufficient to enhance prostate intraepithelial neoplasia (PIN) and microinvasive carcinoma in a mouse model. We found that animals with a genetic predilection for dysregulation of wnt signaling, Apc (Min/+) mutant mice, were significantly susceptible to prostate cancer in an inflammation-dependent manner following infection w ...[more]