Dataset Information

Changing patterns of anal canal carcinoma in the United States.

ABSTRACT:

Purpose

Persistent human papillomavirus infection is associated with squamous cell carcinoma of the anal canal (SCCA). With changing sexual behaviors, SCCA incidence and patient demographics may also have changed in recent years.

Methods

The Surveillance, Epidemiology, and End Results public-use data set from 1973 to 2009 was analyzed to determine incidence trends for and demographic factors characterizing SCCA. Joinpoint analyses identified time points when incidence rates changed. For comparison, similar analyses were conducted for anal adenocarcinoma.

Results

Joinpoint analyses identified 1997 as the single inflection point among 11,231 patients with SCCA, at which the slope of incidence rates statistically increased (1997 to 2009 v 1973 to 1996: risk ratio [RR], 2.2; 95% CI, 2.1 to 2.3). Annual percent change (APC) increased for all SCCA stages and was the greatest for anal carcinoma in situ (CIS; APC, 14.2; 95% CI, 10.2 to 18.4). Demographic changes characterizing later versus earlier time period included younger age at diagnosis and rising incidence rates in all stage, sex, and racial groups. During 1997 to 2009, women were less likely to present with CIS (RR, 0.3; 95% CI, 0.3 to 0.3) but more likely to present with localized (RR, 1.2; 95% CI, 1.1 to 1.3) and regional SCCA (RR, 1.5; 95% CI, 1.4 to 1.7). In contrast, adenocarcinoma APCs among 1,791 patients remained stable during this time period.

Conclusion

CIS and SCCA incidence increased dramatically after 1997 for men and women, although men were more likely to be diagnosed with CIS. These changes likely resulted from available screening in men and argue for efforts to identify high-risk individuals who may benefit from screening.

SUBMITTER: Nelson RA

PROVIDER: S-EPMC3753461 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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Publications

Changing patterns of anal canal carcinoma in the United States.

Nelson Rebecca A RA Levine Alexandra M AM Bernstein Leslie L Smith David D DD Lai Lily L LL

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20130318 12

<h4>Purpose</h4>Persistent human papillomavirus infection is associated with squamous cell carcinoma of the anal canal (SCCA). With changing sexual behaviors, SCCA incidence and patient demographics may also have changed in recent years.<h4>Methods</h4>The Surveillance, Epidemiology, and End Results public-use data set from 1973 to 2009 was analyzed to determine incidence trends for and demographic factors characterizing SCCA. Joinpoint analyses identified time points when incidence rates change ...[more]

PMID: 23509304

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Dataset Information

Changing patterns of anal canal carcinoma in the United States.

Purpose

Methods

Results

Conclusion

Publications

Changing patterns of anal canal carcinoma in the United States.

Similar Datasets

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