Ontology highlight
ABSTRACT:
SUBMITTER: Fabrowski P
PROVIDER: S-EPMC3753550 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Nature communications 20130101
During morphogenesis, remodelling of cell shape requires the expansion or contraction of plasma membrane domains. Here we identify a mechanism underlying the restructuring of the apical surface during epithelial morphogenesis in Drosophila. We show that the retraction of villous protrusions and subsequent apical plasma membrane flattening is an endocytosis-driven morphogenetic process. Quantitation of endogenously tagged GFP::Rab5 dynamics reveals a massive increase in apical endocytosis that co ...[more]