Distance-dependent duplex DNA destabilization proximal to G-quadruplex/i-motif sequences.

ABSTRACT: G-quadruplexes and i-motifs are complementary examples of non-canonical nucleic acid substructure conformations. G-quadruplex thermodynamic stability has been extensively studied for a variety of base sequences, but the degree of duplex destabilization that adjacent quadruplex structure formation can cause has yet to be fully addressed. Stable in vivo formation of these alternative nucleic acid structures is likely to be highly dependent on whether sufficient spacing exists between neighbouring duplex- and quadruplex-/i-motif-forming regions to accommodate quadruplexes or i-motifs without disrupting duplex stability. Prediction of putative G-quadruplex-forming regions is likely to be assisted by further understanding of what distance (number of base pairs) is required for duplexes to remai

SUBMITTER: Konig SL 

PROVIDER: S-EPMC3753619 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature