Ontology highlight
ABSTRACT:
SUBMITTER: van Iterson M
PROVIDER: S-EPMC3753644 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
van Iterson Maarten M Bervoets Sander S de Meijer Emile J EJ Buermans Henk P HP 't Hoen Peter A C PA Menezes Renée X RX Boer Judith M JM
Nucleic acids research 20130614 15
Current microRNA target predictions are based on sequence information and empirically derived rules but do not make use of the expression of microRNAs and their targets. This study aimed to improve microRNA target predictions in a given biological context, using in silico predictions, microRNA and mRNA expression. We used target prediction tools to produce lists of predicted targets and used a gene set test designed to detect consistent effects of microRNAs on the joint expression of multiple ta ...[more]