Ontology highlight
ABSTRACT:
SUBMITTER: Mou H
PROVIDER: S-EPMC3754068 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Mou Huihui H Raj V Stalin VS van Kuppeveld Frank J M FJ Rottier Peter J M PJ Haagmans Bart L BL Bosch Berend Jan BJ
Journal of virology 20130619 16
The spike (S) protein of the recently emerged human Middle East respiratory syndrome coronavirus (MERS-CoV) mediates infection by binding to the cellular receptor dipeptidyl peptidase 4 (DPP4). Here we mapped the receptor binding domain in the S protein to a 231-amino-acid fragment (residues 358 to 588) by evaluating the interaction of spike truncation variants with receptor-expressing cells and soluble DPP4. Antibodies to this domain--much less so those to the preceding N-terminal region--effic ...[more]