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Structure of the C-terminal domain of lettuce necrotic yellows virus phosphoprotein.

ABSTRACT: Lettuce necrotic yellows virus (LNYV) is a prototype of the plant-adapted cytorhabdoviruses. Through a meta-prediction of disorder, we localized a folded C-terminal domain in the amino acid sequence of its phosphoprotein. This domain consists of an autonomous folding unit that is monomeric in solution. Its structure, solved by X-ray crystallography, reveals a lollipop-shaped structure comprising five helices. The structure is different from that of the corresponding domains of other Rhabdoviridae, Filoviridae, and Paramyxovirinae; only the overall topology of the polypeptide chain seems to be conserved, suggesting that this domain evolved under weak selective pressure and varied in size by the acquisition or loss of functional modules.

SUBMITTER: Martinez N

PROVIDER: S-EPMC3754093 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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Structure of the C-terminal domain of lettuce necrotic yellows virus phosphoprotein.

Martinez Nicolas N Ribeiro Euripedes A EA Leyrat Cédric C Tarbouriech Nicolas N Ruigrok Rob W H RW Jamin Marc M

Journal of virology 20130619 17

Lettuce necrotic yellows virus (LNYV) is a prototype of the plant-adapted cytorhabdoviruses. Through a meta-prediction of disorder, we localized a folded C-terminal domain in the amino acid sequence of its phosphoprotein. This domain consists of an autonomous folding unit that is monomeric in solution. Its structure, solved by X-ray crystallography, reveals a lollipop-shaped structure comprising five helices. The structure is different from that of the corresponding domains of other Rhabdovirida ...[more]

PMID: 23785215

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