Ontology highlight
ABSTRACT:
SUBMITTER: Cha J
PROVIDER: S-EPMC3754274 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Cha Jeeyeon J Bartos Amanda A Egashira Mahiro M Haraguchi Hirofumi H Saito-Fujita Tomoko T Leishman Emma E Bradshaw Heather H Dey Sudhansu K SK Hirota Yasushi Y
The Journal of clinical investigation 20130827 9
There are currently more than 15 million preterm births each year. We propose that gene-environment interaction is a major contributor to preterm birth. To address this experimentally, we generated a mouse model with uterine deletion of Trp53, which exhibits approximately 50% incidence of spontaneous preterm birth due to premature decidual senescence with increased mTORC1 activity and COX2 signaling. Here we provide evidence that this predisposition provoked preterm birth in 100% of females expo ...[more]