Ontology highlight
ABSTRACT:
SUBMITTER: Lopez-Rojas R
PROVIDER: S-EPMC3754302 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20130708 9
The fitness and virulence costs associated with the clinical acquisition of colistin resistance by Acinetobacter baumannii were evaluated. The growth of strain CR17 (colistin resistant) was less than that of strain CS01 (colistin susceptible) when the strains were grown in competition (72-h competition index, 0.008). In a murine sepsis model, CS01 and CR17 reached spleen concentrations when coinfecting of 9.31 and 6.97 log10 CFU/g, respectively, with an in vivo competition index of 0.016. Moreov ...[more]