Ontology highlight
ABSTRACT:
SUBMITTER: Ali H
PROVIDER: S-EPMC3754434 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Ali Hazem H Kilic Gokhan G Vincent Kathleen K Motamedi Massoud M Rytting Erik E
Therapeutic delivery 20130201 2
<h4>Background</h4>The purpose of this work was to engineer polymeric nanoparticles to encapsulate and deliver 2-methoxyestradiol, a potential antitumor drug for treatment of uterine leiomyoma (fibroids), the most common hormone-dependent pathology affecting women of reproductive age.<h4>Methods/results</h4>Encapsulation efficiency and drug release from the nanoparticles were monitored by HPLC. Cell morphology and in vitro cytotoxicity experiments were carried out in a human leiomyoma cell line. ...[more]