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Facilitating cytokine-mediated cancer cell death by proteobacterial N-acylhomoserine lactones.

ABSTRACT: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) preferentially induces apoptosis in cancer cells over normal cells; however, tumor cells may develop TRAIL resistance. Here, we demonstrate that this resistance can be overcome in the presence of bacterial acylhomoserine lactones (AHLs) or AHL-producing bacteria through the combined effect of TRAIL-induced apoptosis and AHL-mediated inhibition of inflammation regulated by NF-?B signaling. This discovery unveils a previously unrecognized symbiotic link between bacteria and host immunosurveillance.

SUBMITTER: Kravchenko V

PROVIDER: S-EPMC3755046 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Facilitating cytokine-mediated cancer cell death by proteobacterial N-acylhomoserine lactones.

Kravchenko Vladimir V Garner Amanda L AL Mathison John J Seit-Nebi Alim A Yu Jing J Gileva Irina P IP Ulevitch Richard R Janda Kim D KD

ACS chemical biology 20130321 6

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) preferentially induces apoptosis in cancer cells over normal cells; however, tumor cells may develop TRAIL resistance. Here, we demonstrate that this resistance can be overcome in the presence of bacterial acylhomoserine lactones (AHLs) or AHL-producing bacteria through the combined effect of TRAIL-induced apoptosis and AHL-mediated inhibition of inflammation regulated by NF-κB signaling. This discovery unveils a previously unrecogn ...[more]

PMID: 23517377

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