Ontology highlight
ABSTRACT:
SUBMITTER: Huang R
PROVIDER: S-EPMC3755495 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Huang Rong R Oh Hyunju H Arrendale Allison A Martin Victoria A VA Galan Jacob J Workman Eric J EJ Stout Jane R JR Walczak Claire E CE Tao W Andy WA Borch Richard F RF Geahlen Robert L RL
Biochemical pharmacology 20130704 5
SH2 domains are attractive targets for chemotherapeutic agents due to their involvement in the formation of protein-protein interactions critical to many signal transduction cascades. Little is known, however, about how synthetic SH2 domain ligands would influence the growth properties of tumor cells or with which intracellular proteins they would interact due to their highly charged nature and enzymatic lability. In this study, a prodrug delivery strategy was used to introduce an enzymatically ...[more]