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Antagonistic regulation by the transcription factors C/EBP? and MITF specifies basophil and mast cell fates.


ABSTRACT: It remains unclear whether basophils and mast cells are derived from a common progenitor. Furthermore, how basophil versus mast cell fate is specified has not been investigated. Here, we have identified a population of granulocyte-macrophage progenitors (GMPs) that were highly enriched in the capacity to differentiate into basophils and mast cells while retaining a limited capacity to differentiate into myeloid cells. We have designated these progenitor cells "pre-basophil and mast cell progenitors" (pre-BMPs). STAT5 signaling was required for the differentiation of pre-BMPs into both basophils and mast cells and was critical for inducing two downstream molecules: C/EBP? and MITF. We have identified C/EBP? as the critical basophil transcription factor for specifying basophil cell fate and MITF as the crucial transcription factor for specifying mast cell fate. C/EBP? and MITF silenced each other's transcription in a directly antagonistic fashion. Our study reveals how basophil and mast cell fate is specified.

SUBMITTER: Qi X 

PROVIDER: S-EPMC3755602 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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Antagonistic regulation by the transcription factors C/EBPα and MITF specifies basophil and mast cell fates.

Qi Xiaopeng X   Hong Jessie J   Chaves Lee L   Zhuang Yonghua Y   Chen Yuhong Y   Wang Demin D   Chabon Jacob J   Graham Brian B   Ohmori Keitaro K   Li Yapeng Y   Huang Hua H  

Immunity 20130718 1


It remains unclear whether basophils and mast cells are derived from a common progenitor. Furthermore, how basophil versus mast cell fate is specified has not been investigated. Here, we have identified a population of granulocyte-macrophage progenitors (GMPs) that were highly enriched in the capacity to differentiate into basophils and mast cells while retaining a limited capacity to differentiate into myeloid cells. We have designated these progenitor cells "pre-basophil and mast cell progenit  ...[more]

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