Ontology highlight
ABSTRACT:
SUBMITTER: Qi X
PROVIDER: S-EPMC3755602 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Qi Xiaopeng X Hong Jessie J Chaves Lee L Zhuang Yonghua Y Chen Yuhong Y Wang Demin D Chabon Jacob J Graham Brian B Ohmori Keitaro K Li Yapeng Y Huang Hua H
Immunity 20130718 1
It remains unclear whether basophils and mast cells are derived from a common progenitor. Furthermore, how basophil versus mast cell fate is specified has not been investigated. Here, we have identified a population of granulocyte-macrophage progenitors (GMPs) that were highly enriched in the capacity to differentiate into basophils and mast cells while retaining a limited capacity to differentiate into myeloid cells. We have designated these progenitor cells "pre-basophil and mast cell progenit ...[more]