Epigenetic aberrant methylation of tumor suppressor genes in small cell lung cancer.
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ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC3755684 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Publications
Epigenetic aberrant methylation of tumor suppressor genes in small cell lung cancer.
Journal of thoracic disease 20130801 4
Small cell lung cancer (SCLC), a special type of lung cancer, is reputed to carry a poor prognosis. The morbidity of SCLC is increasing in China and other countries. A variety of DNA alterations associated with non-small cell lung cancer (NSCLC) have been described. However, genetic and epigenetic changes of SCLC are not well established. Few studies have demonstrated that epigenetic silencing of key tumor suppressor genes (TSGs) is pivotal to initiation and development of SCLC. Recently, promot ...[more]
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