Ontology highlight
ABSTRACT:
SUBMITTER: Merianda TT
PROVIDER: S-EPMC3755718 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Merianda Tanuja T TT Gomes Cynthia C Yoo Soonmoon S Vuppalanchi Deepika D Twiss Jeffery L JL
The Journal of neuroscience : the official journal of the Society for Neuroscience 20130801 34
Many neuronal mRNAs are actively transported into distal axons. The 3' untranslated regions (UTRs) of axonal mRNAs often contain cues for their localization. The 3' UTR of neuritin mRNA was shown to be sufficient for localization into axons of hippocampal neurons. Here, we show that neuritin mRNA localizes into axons of rat sensory neurons, but this is predominantly driven by the 5' rather than 3' UTR. Neuritin mRNA shifts from cell body to axon predominantly after nerve crush injury, suggesting ...[more]