Ontology highlight
ABSTRACT:
SUBMITTER: Pashkova N
PROVIDER: S-EPMC3755756 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Pashkova Natasha N Gakhar Lokesh L Winistorfer Stanley C SC Sunshine Anna B AB Rich Matthew M Dunham Maitreya J MJ Yu Liping L Piper Robert C RC
Developmental cell 20130530 5
Sorting of ubiquitinated membrane proteins into lumenal vesicles of multivesicular bodies is mediated by the Endosomal Sorting Complex Required for Transport (ESCRT) apparatus and accessory proteins such as Bro1, which recruits the deubiquitinating enzyme Doa4 to remove ubiquitin from cargo. Here we propose that Bro1 works as a receptor for the selective sorting of ubiquitinated cargoes. We found synthetic genetic interactions between BRO1 and ESCRT-0, suggesting that Bro1 functions similarly to ...[more]