Ontology highlight
ABSTRACT:
SUBMITTER: Feng Y
PROVIDER: S-EPMC3755891 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Feng Yan Y Wang Ye Y Wang Zuoyun Z Fang Zhaoyuan Z Li Fei F Gao Yijun Y Liu Hongyan H Xiao Tian T Li Fuming F Zhou Yang Y Zhai Qiwei Q Liu Xiaolong X Sun Yihua Y Bardeesy Nabeel N Wong Kwok-kin KK Chen Haiquan H Xiong Zhi-qi ZQ Ji Hongbin H
Cancer research 20121016 24
Somatic mutation of the tumor suppressor gene LKB1 occurs frequently in lung cancer where it causes tumor progression and metastasis, but the underlying mechanisms remain mainly unknown. Here, we show that the oncogene NEDD9 is an important downstream mediator of lung cancer progression evoked by LKB1 loss. In de novo mouse models, RNAi-mediated silencing of Nedd9 inhibited lung tumor progression, whereas ectopic NEDD9 expression accelerated this process. Mechanistically, LKB1 negatively regulat ...[more]