Impairment of pancreatic β-cell function by chronic intermittent hypoxia.

ABSTRACT:

New findings

What is the central question of this study? Periodic decreases in arterial blood O2 or chronic intermittent hypoxia (CIH) is a hallmark feature of sleep apnoea patients. Despite a large body of clinical evidence linking sleep disordered breathing with apnoeas to diabetes, the causal relationships between CIH and β-cell function and the underlying molecular mechanisms have not been established. What is the main finding and its importance? In a rodent model, we show that mitochondrial oxidative stress generated by CIH leads to pancreatic β-cell dysfunction manifested by augmented basal insulin secretion, insulin resistance, defective proinsulin processing and impaired glucose-stimulated insulin secretion. The results of the present study provide evidence for direct effec

SUBMITTER: Wang N 

PROVIDER: S-EPMC3756548 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature