Ontology highlight
ABSTRACT:
SUBMITTER: Herlihy SE
PROVIDER: S-EPMC3756559 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Herlihy Sarah E SE Pilling Darrell D Maharjan Anu S AS Gomer Richard H RH
Journal of immunology (Baltimore, Md. : 1950) 20130515 12
In Dictyostelium discoideum, AprA is a secreted protein that inhibits proliferation and causes chemorepulsion of Dictyostelium cells, yet AprA has little sequence similarity to any human proteins. We found that a predicted structure of AprA has similarity to human dipeptidyl peptidase IV (DPPIV). DPPIV is a serine protease present in extracellular fluids that cleaves peptides with a proline or alanine in the second position. In Insall chambers, DPPIV gradients below, similar to, and above the hu ...[more]