Ontology highlight
ABSTRACT:
SUBMITTER: Asuthkar S
PROVIDER: S-EPMC3756915 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Asuthkar Swapna S Stepanova Victoria V Lebedeva Tatiana T Holterman Aixuan L AL Estes Norman N Cines Douglas B DB Rao Jasti S JS Gondi Christopher S CS
Molecular biology of the cell 20130717 17
Pancreatic ductal adenocarcinoma (PDAC) is almost always lethal. One of the underlying reasons for this lethality is believed to be the presence of cancer stem cells (CSC), which impart chemoresistance and promote recurrence, but the mechanisms responsible are unclear. Recently the poor prognosis of PDAC has been correlated with increased expression of urokinase plasminogen activator (uPA). In the present study we examine the role of uPA in the generation of PDAC CSC. We observe a subset of cell ...[more]