Ontology highlight
ABSTRACT:
SUBMITTER: Czech A
PROVIDER: S-EPMC3757041 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Czech Andreas A Wende Sandra S Mörl Mario M Pan Tao T Ignatova Zoya Z
PLoS genetics 20130829 8
Stress-induced changes of gene expression are crucial for survival of eukaryotic cells. Regulation at the level of translation provides the necessary plasticity for immediate changes of cellular activities and protein levels. In this study, we demonstrate that exposure to oxidative stress results in a quick repression of translation by deactivation of the aminoacyl-ends of all transfer-RNA (tRNA). An oxidative-stress activated nuclease, angiogenin, cleaves first within the conserved single-stran ...[more]