Ontology highlight
ABSTRACT:
SUBMITTER: Vora M
PROVIDER: S-EPMC3757059 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Vora Mehul M Shah Mitalie M Ostafi Silvana S Onken Brian B Xue Jian J Ni Julie Zhouli JZ Gu Sam S Driscoll Monica M
PLoS genetics 20130829 8
Caloric/dietary restriction (CR/DR) can promote longevity and protect against age-associated disease across species. The molecular mechanisms coordinating food intake with health-promoting metabolism are thus of significant medical interest. We report that conserved Caenorhabditis elegans microRNA-80 (mir-80) is a major regulator of the DR state. mir-80 deletion confers system-wide healthy aging, including maintained cardiac-like and skeletal muscle-like function at advanced age, reduced accumul ...[more]