Ontology highlight
ABSTRACT:
SUBMITTER: Vitturi DA
PROVIDER: S-EPMC3757223 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Vitturi Dario A DA Chen Chen-Shan CS Woodcock Steven R SR Salvatore Sonia R SR Bonacci Gustavo G Koenitzer Jeffrey R JR Stewart Nicolas A NA Wakabayashi Nobunao N Kensler Thomas W TW Freeman Bruce A BA Schopfer Francisco J FJ
The Journal of biological chemistry 20130722 35
Inflammation, characterized by the activation of both resident and infiltrated immune cells, is accompanied by increased production of oxidizing and nitrating species. Nitrogen dioxide, the proximal nitrating species formed under these conditions, reacts with unsaturated fatty acids to yield nitroalkene derivatives. These electrophilic products modulate protein function via post-translational modification of susceptible nucleophilic amino acids. Nitroalkenes react with Keap1 to instigate Nrf2 si ...[more]