Ontology highlight
ABSTRACT:
SUBMITTER: Koss B
PROVIDER: S-EPMC3757371 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Koss Brian B Morrison Jeffrey J Perciavalle Rhonda M RM Singh Harpreet H Rehg Jerold E JE Williams Richard T RT Opferman Joseph T JT
Blood 20130723 9
The response of Philadelphia chromosome (Ph(+)) acute lymphoblastic leukemia (ALL) to treatment by BCR-ABL tyrosine kinase inhibitors (TKIs) has been disappointing, often resulting in short remissions typified by rapid outgrowth of drug-resistant clones. Therefore, new treatments are needed to improve outcomes for Ph(+) ALL patients. In a mouse model of Ph(+) B-lineage ALL, MCL-1 expression is dysregulated by the BCR-ABL oncofusion protein, and TKI treatment results in loss of MCL-1 expression p ...[more]