Ontology highlight
ABSTRACT:
SUBMITTER: Linger RM
PROVIDER: S-EPMC3757372 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Linger Rachel M A RM Lee-Sherick Alisa B AB DeRyckere Deborah D Cohen Rebecca A RA Jacobsen Kristen M KM McGranahan Amy A Brandão Luis N LN Winges Amanda A Sawczyn Kelly K KK Liang Xiayuan X Keating Amy K AK Tan Aik Choon AC Earp H Shelton HS Graham Douglas K DK
Blood 20130716 9
Acute lymphoblastic leukemia (ALL) is currently treated with an intense regimen of chemotherapy yielding cure rates near 85%. However, alterations to treatment strategies using available drugs are unlikely to provide significant improvement in survival or decrease therapy-associated toxicities. Here, we report ectopic expression of the Mer receptor tyrosine kinase in pre-B-cell ALL (B-ALL) cell lines and pediatric patient samples. Inhibition of Mer in B-ALL cell lines decreased activation of AKT ...[more]