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Triple helical recognition of pyrimidine inversions in polypurine tracts of RNA by nucleobase-modified PNA.


ABSTRACT: Peptide nucleic acids containing 2-pyrimidinone (P) and 3-oxo-2,3-dihydropyridazine (E) heterocycles recognized C-G and U-A inversions in a polypurine tract of double helical RNA with high affinity and sequence selectivity at pH 6.25. E-modified PNA bound strongly to bacterial A-site RNA, while no binding was observed to the human A-site RNA.

SUBMITTER: Gupta P 

PROVIDER: S-EPMC3757498 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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Triple helical recognition of pyrimidine inversions in polypurine tracts of RNA by nucleobase-modified PNA.

Gupta Pankaj P   Zengeya Thomas T   Rozners Eriks E  

Chemical communications (Cambridge, England) 20110912 39


Peptide nucleic acids containing 2-pyrimidinone (P) and 3-oxo-2,3-dihydropyridazine (E) heterocycles recognized C-G and U-A inversions in a polypurine tract of double helical RNA with high affinity and sequence selectivity at pH 6.25. E-modified PNA bound strongly to bacterial A-site RNA, while no binding was observed to the human A-site RNA. ...[more]

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