Ontology highlight
ABSTRACT:
SUBMITTER: Gupta P
PROVIDER: S-EPMC3757498 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Gupta Pankaj P Zengeya Thomas T Rozners Eriks E
Chemical communications (Cambridge, England) 20110912 39
Peptide nucleic acids containing 2-pyrimidinone (P) and 3-oxo-2,3-dihydropyridazine (E) heterocycles recognized C-G and U-A inversions in a polypurine tract of double helical RNA with high affinity and sequence selectivity at pH 6.25. E-modified PNA bound strongly to bacterial A-site RNA, while no binding was observed to the human A-site RNA. ...[more]