Ontology highlight
ABSTRACT:
SUBMITTER: Johnston AP
PROVIDER: S-EPMC3757738 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Johnston Adam P W AP Naska Sibel S Jones Karen K Jinno Hiroyuki H Kaplan David R DR Miller Freda D FD
Stem cell reports 20130604 1
Nerve-derived neural crest cells are essential for regeneration in certain animals, such as newts. Here, we asked whether they play a similar role during mammalian tissue repair, focusing on Sox2-positive neural crest precursors in skin. In adult skin, Sox2 was expressed in nerve-terminal-associated neural crest precursor cells (NCPCs) around the hair follicle bulge, and following injury was induced in nerve-derived cells, likely dedifferentiated Schwann cell precursors. At later times postinjur ...[more]