Ontology highlight
ABSTRACT:
SUBMITTER: Lukens JR
PROVIDER: S-EPMC3758236 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Lukens John R JR Barr Maggie J MJ Chaplin David D DD Chi Hongbo H Kanneganti Thirumala-Devi TD
Journal of immunology (Baltimore, Md. : 1950) 20120217 7
Recent findings have demonstrated an indispensable role for GM-CSF in the pathogenesis of experimental autoimmune encephalomyelitis. However, the signaling pathways and cell populations that regulate GM-CSF production in vivo remain to be elucidated. Our work demonstrates that IL-1R is required for GM-CSF production after both TCR- and cytokine-induced stimulation of immune cells in vitro. Conventional αβ and γδ T cells were both identified to be potent producers of GM-CSF. Moreover, secretion o ...[more]