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Dependence of brain intravoxel incoherent motion perfusion parameters on the cardiac cycle.


ABSTRACT: Measurement of microvascular perfusion with Intravoxel Incoherent Motion (IVIM) MRI is gaining interest. Yet, the physiological influences on the IVIM perfusion parameters ("pseudo-diffusion" coefficient D*, perfusion fraction f, and flow related parameter fD*) remain insufficiently characterized. In this article, we hypothesize that D* and fD*, which depend on blood speed, should vary during the cardiac cycle. We extended the IVIM model to include time dependence of D*?=?D*(t), and demonstrate in the healthy human brain that both parameters D* and fD* are significantly larger during systole than diastole, while the diffusion coefficient D and f do not vary significantly. The results non-invasively demonstrate the pulsatility of the brain's microvasculature.

SUBMITTER: Federau C 

PROVIDER: S-EPMC3758329 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Dependence of brain intravoxel incoherent motion perfusion parameters on the cardiac cycle.

Federau Christian C   Hagmann Patric P   Maeder Philippe P   Müller Markus M   Meuli Reto R   Stuber Matthias M   O'Brien Kieran K  

PloS one 20130830 8


Measurement of microvascular perfusion with Intravoxel Incoherent Motion (IVIM) MRI is gaining interest. Yet, the physiological influences on the IVIM perfusion parameters ("pseudo-diffusion" coefficient D*, perfusion fraction f, and flow related parameter fD*) remain insufficiently characterized. In this article, we hypothesize that D* and fD*, which depend on blood speed, should vary during the cardiac cycle. We extended the IVIM model to include time dependence of D* = D*(t), and demonstrate  ...[more]

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