Pervasive genetic hitchhiking and clonal interference in forty evolving yeast populations.
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ABSTRACT:
SUBMITTER: Lang GI
PROVIDER: S-EPMC3758440 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Publications
Pervasive genetic hitchhiking and clonal interference in forty evolving yeast populations.
Lang Gregory I GI Rice Daniel P DP Hickman Mark J MJ Sodergren Erica E Weinstock George M GM Botstein David D Desai Michael M MM
Nature 20130721 7464
The dynamics of adaptation determine which mutations fix in a population, and hence how reproducible evolution will be. This is central to understanding the spectra of mutations recovered in the evolution of antibiotic resistance, the response of pathogens to immune selection, and the dynamics of cancer progression. In laboratory evolution experiments, demonstrably beneficial mutations are found repeatedly, but are often accompanied by other mutations with no obvious benefit. Here we use whole-g ...[more]
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