Ontology highlight
ABSTRACT:
SUBMITTER: Ma M
PROVIDER: S-EPMC3758452 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Ma Ming M Tian Xin X Igarashi Peter P Pazour Gregory J GJ Somlo Stefan S
Nature genetics 20130728 9
Kidney cysts occur following inactivation of polycystins in otherwise intact cilia or following complete removal of cilia by inactivation of intraflagellar transport-related proteins. We investigated the mechanisms of cyst formation in these two distinct processes by combining conditional inactivation of polycystins with concomitant ablation of cilia in developing and adult kidney and liver. We found that loss of intact cilia suppressed cyst growth following inactivation of polycystins and that ...[more]