Ontology highlight
ABSTRACT:
SUBMITTER: Zhou S
PROVIDER: S-EPMC3758467 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Zhou Shou S Rynearson Kevin D KD Ding Kejia K Brunn Nicholas D ND Hermann Thomas T
Bioorganic & medicinal chemistry 20130402 20
The highly conserved internal ribosome entry site (IRES) of hepatitis C virus (HCV) regulates translation of the viral RNA genome and is essential for the expression of HCV proteins in infected host cells. The structured subdomain IIa of the IRES element is the target site of recently discovered benzimidazole inhibitors that selectively block viral translation through capture of an extended conformation of an RNA internal loop. Here, we describe the development of a FRET-based screening assay fo ...[more]