Ontology highlight
ABSTRACT:
SUBMITTER: Savitz J
PROVIDER: S-EPMC3758772 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Savitz Jonathan J Hodgkinson Colin A CA Martin-Soelch Chantal C Shen Pei-Hong PH Szczepanik Joanna J Nugent Allison C AC Herscovitch Peter P Grace Anthony A AA Goldman David D Drevets Wayne C WC
The international journal of neuropsychopharmacology 20130520 9
The A1 allele of the DRD2/ANKK1 Taq1A polymorphism (rs1800497) is associated with reduced striatal D(2/3) receptor binding in healthy individuals (Con) as well as depression and addiction. However, the effect of rs1800497 on D(2/3) receptor binding in depressed patients as well as the SNP's effect on D(2/3) binding during reward-associated dopamine release is unknown. Twelve unmedicated patients with major depressive disorder (MDD) and 24 Con completed PET scans with [(11)C]raclopride, once with ...[more]