Ontology highlight
ABSTRACT:
SUBMITTER: Labuta J
PROVIDER: S-EPMC3759048 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Labuta Jan J Ishihara Shinsuke S Šikorský Tomáš T Futera Zdeněk Z Shundo Atsuomi A Hanyková Lenka L Burda Jaroslav V JV Ariga Katsuhiko K Hill Jonathan P JP
Nature communications 20130101
Enantiomeric excess of chiral compounds is a key parameter that determines their activity or therapeutic action. The current paradigm for rapid measurement of enantiomeric excess using NMR is based on the formation of diastereomeric complexes between the chiral analyte and a chiral resolving agent, leading to (at least) two species with no symmetry relationship. Here we report an effective method of enantiomeric excess determination using a symmetrical achiral molecule as the resolving agent, wh ...[more]