Aberrant signaling pathways in glioma.
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ABSTRACT:
SUBMITTER: Nakada M
PROVIDER: S-EPMC3759196 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Publications
Aberrant signaling pathways in glioma.
Nakada Mitsutoshi M Kita Daisuke D Watanabe Takuya T Hayashi Yutaka Y Teng Lei L Pyko Ilya V IV Hamada Jun-Ichiro J
Cancers 20110810 3
Glioblastoma multiforme (GBM), a WHO grade IV malignant glioma, is the most common and lethal primary brain tumor in adults; few treatments are available. Median survival rates range from 12-15 months. The biological characteristics of this tumor are exemplified by prominent proliferation, active invasiveness, and rich angiogenesis. This is mainly due to highly deregulated signaling pathways in the tumor. Studies of these signaling pathways have greatly increased our understanding of the biology ...[more]
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