Ontology highlight
ABSTRACT:
SUBMITTER: Holmes DL
PROVIDER: S-EPMC3759520 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Holmes Daniel L DL Lancaster Alex K AK Lindquist Susan S Halfmann Randal R
Cell 20130301 1
Prion proteins undergo self-sustaining conformational conversions that heritably alter their activities. Many of these proteins operate at pivotal positions in determining how genotype is translated into phenotype. But the breadth of prion influences on biology and their evolutionary significance are just beginning to be explored. We report that a prion formed by the Mot3 transcription factor, [MOT3(+)], governs the acquisition of facultative multicellularity in the budding yeast Saccharomyces c ...[more]