Ontology highlight
ABSTRACT:
SUBMITTER: Cai A
PROVIDER: S-EPMC3759991 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Cai Ann A Keskin Derin B DB DeLuca David S DS Alonso Anselmo A Zhang Wandi W Zhang Guang Lan GL Hammond Naa Norkor NN Nardi Valentina V Stone Richard M RM Neuberg Donna D Sidney John J Brusic Vladimir V Wu Catherine J CJ
Clinical cancer research : an official journal of the American Association for Cancer Research 20120821 20
<h4>Purpose</h4>Characterization of an approach to identify leukemia neoantigens arising in the context of drug resistance.<h4>Experimental design</h4>We assessed whether leukemia neoantigens could be generated from drug-resistant mutations in BCR-ABL after imatinib relapse in patients with chronic myelogenous leukemia (CML).<h4>Results</h4>We computationally predicted that approximately 70 peptides derived from 26 BCR-ABL mutations would bind eight common alleles of MHC class I (IC(50) < 1,000 ...[more]