Ontology highlight
ABSTRACT:
SUBMITTER: Lukacs C
PROVIDER: S-EPMC3760131 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Lukacs Christine C Belunis Charles C Crowther Robert R Danho Waleed W Gao Lin L Goggin Barry B Janson Cheryl A CA Li Shirley S Remiszewski Stacy S Schutt Andrew A Thakur Manish K MK Singh Saroj K SK Swaminathan Srinivasan S Pandey Rajat R Tyagi Rajiv R Gosu Ramachandraiah R Kamath Ajith V AV Kuglstatter Andreas A
Acta crystallographica. Section D, Biological crystallography 20130815 Pt 9
XIAP, a member of the inhibitor of apoptosis family of proteins, is a critical regulator of apoptosis. Inhibition of the BIR domain-caspase interaction is a promising approach towards treating cancer. Previous work has been directed towards inhibiting the BIR3-caspase-9 interaction, which blocks the intrinsic apoptotic pathway; selectively inhibiting the BIR2-caspase-3 interaction would also block the extrinsic pathway. The BIR2 domain of XIAP has successfully been crystallized; peptides and sma ...[more]