Altered overnight modulation of spontaneous waking EEG reflects altered sleep homeostasis in major depressive disorder: a high-density EEG investigation.

ABSTRACT:

Background

Prior investigations have suggested sleep homeostasis is altered in major depressive disorder (MDD). Low frequency activity (LFA) in the electroencephalogram during waking has been correlated with sleep slow wave activity (SWA), suggesting that waking LFA reflects sleep homeostasis in healthy individuals. This study investigated whether the overnight change in waking LFA and its relationship with sleep SWA are altered in MDD.

Methods

256-channel high-density electroencephalography (hdEEG) recordings during waking (pre- and post-sleep) and during sleep were collected in 14 unmedicated, unipolar MDD subjects (9 women) and age- and sex-matched healthy controls (HC).

Results

Waking LFA (3.25-6.25 Hz) declined significantly overnight in the HC group, but not in

SUBMITTER: Plante DT 

PROVIDER: S-EPMC3760229 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature