Ontology highlight
ABSTRACT:
SUBMITTER: Nuccitelli R
PROVIDER: S-EPMC3760242 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Nuccitelli Richard R Tran Kevin K Lui Kaying K Huynh Joanne J Athos Brian B Kreis Mark M Nuccitelli Pamela P De Fabo Edward C EC
Pigment cell & melanoma research 20120901 5
Non-thermal nanoelectroablation therapy completely ablates UV-induced murine melanomas. C57/BL6-HGF/SF transgenic mice were exposed to UV radiation as pups and began to develop visible melanomas 5-6 months later. We have treated 27 of these melanomas in 14 mice with nanosecond pulsed electric field (nsPEF) therapy delivering 2000 electric pulses each 100 ns long and 30 kV/cm at a rate of 5-7 pulses per second. All nanoelectroablated melanoma tumors began to shrink within a day after treatment an ...[more]