Ontology highlight
ABSTRACT:
SUBMITTER: Venkatesh D
PROVIDER: S-EPMC3760474 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Venkatesh Deepak D Ernandez Thomas T Rosetti Florencia F Batal Ibrahim I Cullere Xavier X Luscinskas Francis W FW Zhang Yuzhi Y Stavrakis George G García-Cardeña Guillermo G Horwitz Bruce H BH Mayadas Tanya N TN
Immunity 20130425 5
Endothelial-dependent mechanisms of mononuclear cell influx are not well understood. We showed that acute stimulation of murine microvascular endothelial cells expressing the tumor necrosis factor receptors TNFR1 and TNFR2 with the soluble cytokine TNF led to CXCR3 chemokine generation. The TNF receptors signaled through interferon regulatory factor-1 (IRF1) to induce interferon-β (IFN-β) and subsequent autocrine signaling via the type I IFN receptor and the transcription factor STAT1. Both TNFR ...[more]