Ontology highlight
ABSTRACT:
SUBMITTER: Ceccarelli J
PROVIDER: S-EPMC3760594 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Ceccarelli Jacob J Cheng Albert A Putnam Andrew J AJ
Cellular and molecular bioengineering 20121201 4
Cyclic strain is known to affect endothelial cell phenotype, but its effects on neovascular pattern formation remain poorly understood. To examine how cyclic strain affects angiogenesis, we designed a stretchable, polydimethylsiloxane (PDMS)-based multi-well system that supports a 3D cell culture model of angiogenesis, consisting of endothelial cells coated onto microcarrier beads embedded in a fibrin gel with a supporting monolayer of smooth muscle cells atop the gel. Calibration of the integra ...[more]