Association between SNP heterozygosity and quantitative traits in the Framingham Heart Study.
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ABSTRACT:
SUBMITTER: Govindaraju DR
PROVIDER: S-EPMC3760672 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
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Association between SNP heterozygosity and quantitative traits in the Framingham Heart Study.
Govindaraju Didahally R DR Larson Martin G MG Yin Xiaoyan X Benjamin Emelia J EJ Rao Marepalli B MB Vasan Ramachandran S RS
Annals of human genetics 20090701 Pt 4
Associations between multilocus heterozygosity and fitness traits, also termed heterozygosity and fitness correlations (HFCs), have been reported in numerous organisms. These studies, in general, indicate a positive relationship between heterozygosity and fitness traits. We studied the association between genome-wide heterozygosity at 706 non-synonymous and synonymous SNPs and 19 quantitative traits, including morphological, biochemical and fitness traits in the Framingham Heart Study. Statistic ...[more]
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