Distortions in genealogies due to purifying selection and recombination.
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ABSTRACT:
SUBMITTER: Nicolaisen LE
PROVIDER: S-EPMC3761303 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Publications
Distortions in genealogies due to purifying selection and recombination.
Nicolaisen Lauren E LE Desai Michael M MM
Genetics 20130702 1
Purifying selection at many linked sites alters patterns of molecular evolution, reducing overall diversity and distorting the shapes of genealogies. Recombination attenuates these effects; however, purifying selection can significantly distort genealogies even for substantial recombination rates. Here, we show that when selection and/or recombination are sufficiently strong, the genealogy at any single site can be described by a time-dependent effective population size, Ne(t), which has a simpl ...[more]
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