Ontology highlight
ABSTRACT:
SUBMITTER: Flick HE
PROVIDER: S-EPMC3762611 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
International journal of tryptophan research : IJTR 20130819
β-lapachone is a naturally occurring 1,2-naphthoquinone-based compound that has been advanced into clinical trials based on its tumor-selective cytotoxic properties. Previously, we focused on the related 1,4-naphthoquinone pharmacophore as a basic core structure for developing a series of potent indoleamine 2,3-dioxygenase 1 (IDO1) enzyme inhibitors. In this study, we identified IDO1 inhibitory activity as a previously unrecognized attribute of the clinical candidate β-lapachone. Enzyme kinetics ...[more]