Ontology highlight
ABSTRACT:
SUBMITTER: Siepka SM
PROVIDER: S-EPMC3762874 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Siepka Sandra M SM Yoo Seung-Hee SH Park Junghea J Song Weimin W Kumar Vivek V Hu Yinin Y Lee Choogon C Takahashi Joseph S JS
Cell 20070426 5
Using a forward genetics ENU mutagenesis screen for recessive mutations that affect circadian rhythmicity in the mouse, we isolated a long period (approximately 26 hr) circadian mutant named Overtime (Ovtm). Positional cloning and genetic complementation reveal that Ovtm is encoded by the F-box protein FBXL3, a component of the SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligase complex. The Ovtm mutation causes an isoleucine to threonine (I364T) substitution leading to a loss of function in FBXL3 ...[more]