Ontology highlight
ABSTRACT:
SUBMITTER: Kjelstrup S
PROVIDER: S-EPMC3762901 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Kjelstrup Susanne S Hansen Paula Melo Paulon PM Thomsen Line E LE Hansen Paul Robert PR Løbner-Olesen Anders A
PloS one 20130904 9
Interaction between pairs of Staphylococcus aureus replication proteins was detected in an Escherichia coli based two-hybrid analysis. A reverse two-hybrid system was constructed for selection of compounds that hindered interaction between interacting protein pairs. A number of cyclic peptides, from a library generated by the split intein-mediated circular ligation of peptides and proteins technology, were found to interfere with dimerization of the β-sliding clamp of the replisome. Two 8-mer pe ...[more]