Ontology highlight
ABSTRACT:
SUBMITTER: Chen QK
PROVIDER: S-EPMC3762919 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Chen Qike K QK Lee KangAe K Radisky Derek C DC Nelson Celeste M CM
Differentiation; research in biological diversity 20130506 3
Mouse mammary epithelial cells undergo transdifferentiation via epithelial-mesenchymal transition (EMT) upon treatment with matrix metalloproteinase-3 (MMP3). In rigid microenvironments, MMP3 upregulates expression of Rac1b, which translocates to the cell membrane to promote induction of reactive oxygen species and EMT. Here we examine the role of the extracellular matrix (ECM) in this process. Our data show that the basement membrane protein laminin suppresses the EMT response in MMP3-treated c ...[more]