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Simulation shows hospitals that cooperate on infection control obtain better results than hospitals acting alone.

ABSTRACT: Efforts to control life-threatening infections, such as with methicillin-resistant Staphylococcus aureus (MRSA), can be complicated when patients are transferred from one hospital to another. Using a detailed computer simulation model of all hospitals in Orange County, California, we explored the effects when combinations of hospitals tested all patients at admission for MRSA and adopted procedures to limit transmission among patients who tested positive. Called "contact isolation," these procedures specify precautions for health care workers interacting with an infected patient, such as wearing gloves and gowns. Our simulation demonstrated that each hospital's decision to test for MRSA and implement contact isolation procedures could affect the MRSA prevalence in all other hospitals. Thus, our study makes the case that further cooperation among hospitals--which is already reflected in a few limited collaborative infection control efforts under way--could help individual hospitals achieve better infection control than they could achieve on their own.

SUBMITTER: Lee BY

PROVIDER: S-EPMC3763190 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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Simulation shows hospitals that cooperate on infection control obtain better results than hospitals acting alone.

Lee Bruce Y BY Bartsch Sarah M SM Wong Kim F KF Yilmaz S Levent SL Avery Taliser R TR Singh Ashima A Song Yeohan Y Kim Diane S DS Brown Shawn T ST Potter Margaret A MA Platt Richard R Huang Susan S SS

Health affairs (Project Hope) 20121001 10

Efforts to control life-threatening infections, such as with methicillin-resistant Staphylococcus aureus (MRSA), can be complicated when patients are transferred from one hospital to another. Using a detailed computer simulation model of all hospitals in Orange County, California, we explored the effects when combinations of hospitals tested all patients at admission for MRSA and adopted procedures to limit transmission among patients who tested positive. Called "contact isolation," these proced ...[more]

PMID: 23048111

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Project description:Single-crystal X-ray diffraction structural results for benzidine dihydrochloride, hydrated and protonated N,N,N,N-peri(dimethylamino)naphthalene chloride, triptycene, dichlorodimethyltriptycene and decamethylferrocene have been analysed. A critical discussion of the dependence of structural and thermal parameters on resolution for these compounds is presented. Results of refinements against X-ray data, cut off to different resolutions from the high-resolution data files, are compared to structural models derived from neutron diffraction experiments. The Independent Atom Model (IAM) and the Transferable Aspherical Atom Model (TAAM) are tested. The average differences between the X-ray and neutron structural parameters (with the exception of valence angles defined by H atoms) decrease with the increasing 2?max angle. The scale of differences between X-ray and neutron geometrical parameters can be significantly reduced when data are collected to the higher, than commonly used, 2?max diffraction angles (for Mo?K? 2?max?>?65°). The final structural and thermal parameters obtained for the studied compounds using TAAM refinement are in better agreement with the neutron values than the IAM results for all resolutions and all compounds. By using TAAM, it is still possible to obtain accurate results even from low-resolution X-ray data. This is particularly important as TAAM is easy to apply and can routinely be used to improve the quality of structural investigations [Dominiak (2015 ?). LSDB from UBDB. University of Buffalo, USA]. We can recommend that, in order to obtain more adequate (more accurate and precise) structural and displacement parameters during the IAM model refinement, data should be collected up to the larger diffraction angles, at least, for Mo?K? radiation to 2?max = 65° (sin??max/??<?0.75?Å(-1)). The TAAM approach is a very good option to obtain more adequate results even using data collected to the lower 2?max angles. Also the results of translation-libration-screw (TLS) analysis and vibrational entropy values are more reliable for 2?max?>?65°.

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Simulation shows hospitals that cooperate on infection control obtain better results than hospitals acting alone.

Publications

Simulation shows hospitals that cooperate on infection control obtain better results than hospitals acting alone.

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